Application of Organophosphate Pesticides may result common occurrence of OP residues in food crops, natural water systems, soil and atmosphere, which will be the major sources of exposure. OP compounds induce immune system damage. The study was conducted on 90 broiler chicks divided into six groups each containing 15 birds to assess the hemato-biochemical, immunological and growth effects of Acephate induced toxicity and its amelioration with vitamin E for a period of 42 days and birds were slaughtered at 2nd, 4th and 6th week. The commercial product of Acephate was incorporated @ 85.2 mg/Kg and 170.4 mg/kg of feed and vitamin E was incorporated into diet @ 300 mg/kg feed.\r\nHaematological parameters like TEC, MCV, MCH and MCHC did not alter but TLC was decreased significantly (P < 0.05) in toxic groups. Serum biochemical parameters including AST, ALT, Creatinine, BUN and A/G ratio were found increased and recorded decreased in level of serum total protein, albumin and globulin but did not alter serum cholesterol levels. Immunological assay in groups II and III revealed significant decreased in NDV titre suggested suppression of humoral immunity but did not alter cell mediated immunity checked with DNCB. Acephate treated groups resulted significant (P < 0.05) decrease in mean body weights. Ameliorating groups showed significant (P < 0.05) improvement in above parameters as compared to toxic groups.\r\n The present study indicated that Acephate at both the dose rates resulted few changes in hemato-biochemical parameters, Immunosupression and effect on body weights and administration of vitamin E alleviated the Immunosupressive effect, improvement in hemato-biochemical alterations that are effected and body weights by Acephate due to its antioxidant property.
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